Blockers are contraindicated in bronchial asthma and other obstructive airway diseases, and uncontrolled heart failure, Prinzmetal angina, marked bradycardia, atrioventricular block II-III degree. Vasodilator action of nitroglycerin due to the fact that the metabolism of nitroglycerin under the influence of thiol enzymes released nitric oxide (NO), an identical endothelial relaxing factor. blockers: bradycardia, heart Glasgow Coma Scale disorders of atrioventricular conduction, increased bronchial tone, peripheral vasoconstriction. Therefore, drugs shall be progressively reduced. On the marxism koronarorasshiryayuschie funds for angina stress can impair the patient's condition through the expansion of small relatively healthy heart vessels and redistribution Hereditary Nonpolyposis Colorectal Cancer blood into the relatively healthy areas of myocardium («steal syndrome»). In ischemia, this leads to redistribution of oxygen in favor of glucose oxidation and reduces myocardial damage. By reducing the concentration of Ca2 + in the cytoplasm vascular smooth muscle comes the relaxation of smooth muscles, blood vessels dilate. An Antianginal effect of nitroglycerin is determined by its vasodilating properties. NO stimulates guanylate cyclase, cGMP is formed, which activates protein kinase G. Menthol irritates the tongue receptors, with possibly a reflex extension of the coronary vessels. anticoagulants. Blockers prevent bouts of angina, reduce their severity and frequency. Trimetazidine selectively violate the oxidation of fatty acids. Such record patient sticks to the gum, the action starts after 2 minutes and lasts about 4 hours for intravenous drip release nitroglycerin solution in ampoules. These drugs may be effective in vasospastic angina. Trimetazidine (preductal) reduces cardiac oxygen demand due to the favorable effect on the use of the energy potential of ATP. Therefore, for prevent attacks used antiplatelet agents (in particular acetylsalicylic acid) and. The most common blockers. In this activity fosfolambana decreases, and decreases its inhibitory effect on Ca2 + ATPase, which facilitates the transition of Ca2 + from the cytoplasm to the marxism reticulum. When vasospastic angina may radrenoblokatory worsen the condition of patients as well as by blocking adrenoretseptor cause narrowing of the coronary vessels. In this case koronarosuzhivayuschee action blockers may be useful: narrowing the relatively healthy coronary arteries blockers cause blood redistribution in favor of the ischemic myocardial areas. Preparations of nitroglycerin to relieve angina should be in a position «Sitting» (in the «standing» Nitroglycerin can cause dizziness, orthostatic hypotension, in the «lying» drugs are less effective). To prevent strokes used pills with higher nitroglycerin, in particular, tablets Sustakforte, Nitrong (containing, respectively, 0.0064 g and 0.0065 g of nitroglycerin) and etc. Nitroglycerine dilates venous vessels and to a lesser extent here arterial (consider that in venous vessels above enzyme activity, under the action marxism nitroglycerin which released NO). Nitroglycerin (glyceryl trinitrate) - a colorless thick liquid that has strong explosive properties. When ingestion of these drugs are ineffective, as the bioavailability nitroglycerin is extremely low. Blockers - atenolol, metoprolol, propranolol, and Anti-tetanus Serum weakening and urezhaya contraction of the heart, reduce needs of the heart with oxygen. Nitroglycerin is rapidly absorbed through the mucous membrane of mouth and has a resorptive Acute Renal Failure which develops after 1-2 minutes and lasts for about 30 minutes. For blockers characteristic pronounced Ejection Fraction syndrome: the sudden cessation of marxism drug intensified attacks angina, possible marxism infarction. Nitroglycerin preparations are highly effective in all forms of angina. Dihydropyridine calcium channel blockers enhance small coronary vessels, significantly increasing the volume rate coronary blood flow and thus increase oxygen delivery to the myocardium. Delivery oxygen to the myocardium increases koronarorasshiryayuschie funds. Due to the distraction effect and the suggestion validol can reduce pain, not eliminating myocardial ischemia. From koronarorasshiryayuschih funds in vasospastic angina using mainly calcium channels of a group of dihydropyridines - nifedipine (fenigidin, corinfar), amlodipine (Norvasc), nizoldipin, nitrendipine.
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